CD9 boosts PEC glomerular invasion

Tetraspanin CD9 regulates invasion during mouse embryo implantation.

The expression of tetraspanin CD9 was found on blastocysts in mice and endometrium epithelial cells in human and bovine. However, it remains unknown how CD9 is involved in the precise dialogue between embryo and uterus during early pregnancy. This study was designed to investigate the functional roles of CD9 in the embryo implantation with monoclonal antibody against CD9 protein (anti-CD9 mAb) ...

Anti-CD9 monoclonal antibody-stimulated invasion of endometrial cancer cell lines in vitro: possible inhibitory effect of CD9 in endometrial cancer invasion.

Cell surface marker CD9 has been reported to play a role in inhibiting trophoblastic cell invasion. Since the invasive properties of cancer cells may resemble those of trophoblasts, we decided to investigate the role of CD9 in the invasion of endometrial cancer cells. In normal human endometrium, CD9 was found to be constitutively expressed on epithelial cells, as reported previously. While epi...

Computer simulation of PEC network

Interconnection network is a decisive component of parallel and distributed computer systems. With the merits of simplicity and eeciency, 2-dimensional (2-D) mesh has been a popular choice of large MIMD interconnection networks. Mesh, however, has its known weaknesses in scalability and connectivity. Packed Exponential Connections (PEC) is a newly proposed network which is designed to improve t...

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma

The systemic and resistant nature of metastatic neuroblastoma renders it largely incurable with current multimodal treatment. Clinical progression stems mainly from the increasing burden of metastatic colonization. Therapeutically inhibiting the migration-invasion-metastasis cascade would be of great benefit, but the mechanisms driving this cycle are as yet poorly understood. In-depth transcrip...

MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma